ea0019p140 | Diabetes, Metabolism and Cardiovascular | SFEBES2009
Abbas A
, Imrie H
, Viswambharan H
, Rajwani A
, Kahn M
, Cubbon R
, Gage M
, Wheatcroft S
, Grant P
, Kearney M
Introduction: Insulin-like growth factor 1 (IGF-1), acting via similar signalling pathways to insulin, enhances glucose uptake and nitric oxide (NO) production. Observational studies suggest a role for (IGF-1) in insulin resistance and cardiovascular disease. To investigate this further we used a murine model with heterozygous knockout of the IGF-1 receptor.Methods: Metabolic tolerance tests were performed in vivo on unanaesthetised mice, heterozy...